| 게재년월 |
2020/08 |
| 논문제목 |
Field-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent
|
| 참여교수 |
윤호근, 손명현
|
| 학술지명 |
CHEMICAL COMMUNICATIONS |
| 초록 |
(E)-3-(3-(4-((3-Carbamoylbenzyl)oxy)-3-iodo-5-methoxyphenyl) acryloyl)benzamide (A6) was found to be a potent p300 inhibitor (IC50 = 870 nM) showing a similar binding mode to that of acetyl-CoA, a p300 substrate, and effective anti-fibrotic activity in both TGF-β1-stimulated lung fibroblast cells and bleomycin-induced in vivo lung fibrosis mice. |
| 게재정보 |
Chem Commun (Camb). 2020 Aug 25;56(68):9795-9798 |
| 총저자명 |
Soo-Yeon Hwang, Soo-Yeon Park, Jung Yeon Hong, Soo Yeon Lee, Jae-Ho Shin, Younghwa Na, Myung Hyun Sohn, Ho-Geun Yoon, Youngjoo Kwon
|
