| 게재년월 | 2021/05 |
|---|---|
| 논문제목 | Club cell-specific role of programmed cell death 5 in pulmonary fibrosis |
| 참여교수 | 윤호근, 손명현 |
| 학술지명 | NATURE COMMUNICATIONS |
| 초록 | Idiopathic pulmonary fibrosis (IPF) causes progressive fibrosis and worsening pulmonary function. Prognosis is poor and no effective therapies exist. We show that programmed cell death 5 (PDCD5) expression is increased in the lungs of patients with IPF and in mouse models of lung fibrosis. Lung fibrosis is significantly diminished by club cell-specific deletion of Pdcd5 gene. PDCD5 mediates β-catenin/Smad3 complex formation, promoting TGF-β-induced transcriptional activation of matricellular genes. Club cell Pdcd5 knockdown reduces matricellular protein secretion, inhibiting fibroblast proliferation and collagen synthesis. Here, we demonstrate the club cell-specific role of PDCD5 as a mediator of lung fibrosis and potential therapeutic target for IPF. |
| 게재정보 | Nat Commun. 2021 May 19;12(1):2923 |
| 총저자명 | Soo-Yeon Park, Jung Yeon Hong, Soo Yeon Lee, Seung-Hyun Lee, Mi Jeong Kim, Soo Yeon Kim, Kyung Won Kim, Hyo Sup Shim, Moo Suk Park, Chun Geun Lee, Jack A. Elias, Myung Hyun Sohn, Ho-Geun Yoon |
