| 게재년월 |
2021/03 |
| 논문제목 |
Activation of KCNQ4 as a Therapeutic Strategy to Treat Hearing Loss
|
| 참여교수 |
지헌영
|
| 학술지명 |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| 초록 |
Potassium voltage-gated channel subfamily q member 4 (KCNQ4) is a voltage-gated potassium channel that plays essential roles in maintaining ion homeostasis and regulating hair cell membrane potential. Reduction of the activity of the KCNQ4 channel owing to genetic mutations is responsible for nonsyndromic hearing loss, a typically late-onset, initially high-frequency loss progressing over time. In addition, variants of KCNQ4 have also been associated with noise-induced hearing loss and age-related hearing loss. Therefore, the discovery of small compounds activating or potentiating KCNQ4 is an important strategy for the curative treatment of hearing loss. In this review, we updated the current concept of the physiological role of KCNQ4 in the inner ear and the pathologic mechanism underlying the role of KCNQ4 variants with regard to hearing loss. Finally, we focused on currently developed KCNQ4 activators and their pros and cons, paving the way for the future development of specific KCNQ4 activators as a remedy for hearing loss. |
| 게재정보 |
Int J Mol Sci.2021 Mar 2;22(5):2510 |
| 총저자명 |
John Hoon Rim, Jae Young Choi, Jinsei Jung, Heon Yung Gee
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