| 게재년월 |
2022/03 |
| 논문제목 |
Loss of MIG-6 results in endometrial progesterone resistance via ERBB2
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| 참여교수 |
윤호근
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| 학술지명 |
Nature Communications |
| 초록 |
Female subfertility is highly associated with endometriosis. Endometrial progesterone resistance is suggested as a crucial element in the development of endometrial diseases. We report that MIG-6 is downregulated in the endometrium of infertile women with endometriosis and in a non-human primate model of endometriosis. We find ERBB2 overexpression in the endometrium of uterine-specific Mig-6 knockout mice (Pgrcre/+Mig-6f/f; Mig-6d/d). To investigate the effect of ERBB2 targeting on endometrial progesterone resistance, fertility, and endometriosis, we introduce Erbb2 ablation in Mig-6d/d mice (Mig-6d/dErbb2d/d mice). The additional knockout of Erbb2 rescues all phenotypes seen in Mig-6d/d mice. Transcriptomic analysis shows that genes differentially expressed in Mig-6d/d mice revert to their normal expression in Mig-6d/dErbb2d/d mice. Together, our results demonstrate that ERBB2 overexpression in endometrium with MIG-6 deficiency causes endometrial progesterone resistance and a nonreceptive endometrium in endometriosis-related infertility, and ERBB2 targeting reverses these effects. |
| 게재정보 |
Nat Commun. 2022 Mar 1;13(1):1101 |
| 총저자명 |
Jung-Yoon Yoo, Tae Hoon Kim, Jung-Ho Shin, Ryan M Marquardt, Ulrich Müller, Asgerally T Fazleabas, Steven L Young, Bruce A Lessey, Ho-Geun Yoon, Jae-Wook Jeong
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